Is there a clinically significant interaction between Pepto Bismol and insulin?

The salicylate present in Pepto Bismol could potentially increase the hypoglycemic effect of insulin. This effect would be especially present with high doses of salicylates. The use of Pepto is not contraindicated in someone taking insulin. However, it is important to monitor blood sugar levels more closely when using Pepto. It is also important to monitor blood sugar levels more often during an episode of illness (gastro, diarrhea, flu) because insulin needs could change in this case. Do not hesitate to contact me if you have any other questions!